Bupropion Hydrochloride Sustained-Release Tablets is an antidepressant medication for the treatment of major types of depression. It is also used to treat seasonal affective disorder SAD , a type of depression that comes and goes with the seasons, mainly affecting patients in the autumn and winter months.
It works by levelling out imbalances of certain brain chemicals called neurotransmitters. Depression occurs when a chemical imbalance occurs in the brain. Experts are not entirely certain on how or why this imbalance occurs, but what is certain is that particular drugs, like Wellbutrin can improve the symptoms which may include strange behaviour or thoughts, suicidal feelings, low motivation, decrease in appetite, weight loss or gain and irritability.
Wellbutrin SR also is used for smoking cessation treatment, but bupropion under the brand name Zyban is approved for this use. Bupropion may affect the mental or physical abilities needed to drive or operate machinery. Avoid driving, operating machinery, or performing other hazardous tasks until you have determined how this medication affects you. It is not known whether bupropion is safe for use by people with a recent history of heart attack or unstable heart disease.
If you have heart problems, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed. If you are taking one of these medications, do not take the other or any other product containing bupropion, as the risk of seizures increases with an increased dosage. Bupropion is removed from the body by the kidney.
Decreased kidney function can cause this medication to build up in the body, causing side effects. If you have kidney disease, discuss with your doctor how this medication may affect your medical condition, how your medical condition may affect the dosing and effectiveness of this medication, and whether any special monitoring is needed.
Consider the possibility of multiple drug overdose. Ensure an adequate airway, oxygenation, and ventilation. Monitor cardiac rhythm and vital signs. Induction of emesis is not recommended.
Its structure closely resembles that of diethylpropion; it is related to phenylethylamines. The molecular weight is Bupropion hydrochloride powder is white, crystalline, and highly soluble in water. It has a bitter taste and produces the sensation of local anesthesia on the oral mucosa. The structural formula is: Each tablet contains the labeled amount of bupropion hydrochloride and the inactive ingredients: Bupropion is a relatively weak inhibitor of the neuronal reuptake of norepinephrine and dopamine, and does not inhibit the reuptake of serotonin.
Bupropion does not inhibit monoamine oxidase. Pharmacokinetics Bupropion is a racemic mixture. The pharmacological activity and pharmacokinetics of the individual enantiomers have not been studied.
Absorption The absolute bioavailability of Wellbutrin SR in humans has not been determined because an intravenous formulation for human use is not available. However, it appears likely that only a small proportion of any orally administered dose reaches the systemic circulation intact. Exposure AUC to bupropion was equivalent for both formulations.
Bioequivalence was also demonstrated for all three major active metabolites i. Wellbutrin SR can be taken with or without food. The food effect is not considered clinically significant. The extent of protein binding of the hydroxybupropion metabolite is similar to that for bupropion; whereas, the extent of protein binding of the threohydrobupropion metabolite is about half that seen with bupropion.
I'm desperate to lose 40 lbs half of which I gained on Zoloft-no longer taking. Read More I was put on Topamax four weeks ago and have been building up to mg. I have been suicidal this week and that is so unlike me. We got a puppy six weeks ago and there have been times that I could drop kick her out the door. My mood swings have been horrendous.
My husband said that I've been like Jeckyl and Hyde. I can lose weight through Weightwatchers. Read More I switched to a combo of effexor and bupropion and with a strict diet I got down to The explaination of weight gain that my new dr told me was pretty good- she explained that since most of the meds are for depression, they alter your mind and stimulate good things - so all the things that you once kept in check - like watching your diet- go out the door.
How should I take bupropion hydrochloride extended-release tablets SR? Take bupropion hydrochloride extended-release tablets SR exactly as prescribed by your doctor. Do not chew, cut, or crush bupropion hydrochloride extended-release tablets SR. If you do, the medicine will be released into your body too quickly. If this happens you may be more likely to get side effects including seizures. You must swallow the tablets whole. Tell your doctor if you cannot swallow medicine tablets.
Take bupropion hydrochloride extended-release tablets SR at the same time each day. Take your doses of bupropion hydrochloride extended-release tablets SR at least 8 hours apart. You may take bupropion hydrochloride extended-release tablets SR with or without food. If you miss a dose, do not take an extra tablet to make up for the dose you forgot. Wait and take your next tablet at the regular time.
This is very important. Too much bupropion hydrochloride extended-release tablets SR can increase your chance of having a seizure. If you take too much bupropion hydrochloride extended-release tablets SR , or overdose, call your local emergency room or poison control center right away. Do not take any other medicines while using bupropion hydrochloride extended-release tablets SR unless your doctor has told you it is okay.
It may take several weeks for you to feel that bupropion hydrochloride extended-release tablets SR is working. Once you feel better, it is important to keep taking bupropion hydrochloride extended-release tablets SR exactly as directed by your doctor. Call your doctor if you do not feel bupropion hydrochloride extended-release tablets SR is working for you.
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